Baumgartner S, Chiquet-Ehrismann R
Friedrich Miescher-Institute, Basel, Switzerland.
Mech Dev. 1993 Mar;40(3):165-76. doi: 10.1016/0925-4773(93)90074-8.
We report the identification and molecular characterization of tena*, a Drosophila gene located at 11A6-9 on the X-chromosome. The deduced protein of 782 amino acids contains eight tenascin-type EGF-like repeats not described in Drosophila before, but lacks the fibronectin type III repeats and the fibrinogen homology present in the vertebrate tenascin molecules. Tena codes for a large transcript which exhibits extremely long 5' and 3' untranslated regions. Tena transcripts show a specific perinuclear localization within cells and are mainly expressed in the central nervous system, in the brain and near muscle attachment sites during embryogenesis. During pupal stages, tena is detected in the eye. These expression patterns are reminiscent of those of vertebrate tenascin. Tenascin-type EGF-like sequences are also detected in other loci of Drosophila and in various other organisms, indicating the existence of a family of genes related to tenascin.
我们报道了tena的鉴定及分子特征，tena是位于果蝇X染色体11A6 - 9位置的一个基因。推导的由782个氨基酸组成的蛋白质含有八个在果蝇中未曾描述过的腱生蛋白型表皮生长因子样重复序列，但缺乏脊椎动物腱生蛋白分子中存在的纤连蛋白III型重复序列和纤维蛋白原同源结构域。Tena编码一个大转录本，该转录本具有极长的5'和3'非翻译区。Tena转录本在细胞内显示出特定的核周定位，并且在胚胎发育过程中主要在中枢神经系统、脑以及肌肉附着位点附近表达。在蛹期，在眼睛中检测到tena。这些表达模式让人联想到脊椎动物腱生蛋白的表达模式。在果蝇的其他基因座以及各种其他生物体中也检测到了腱生蛋白型表皮生长因子样序列，这表明存在一个与腱生蛋白相关的基因家族。
