Giustina A, Licini M, Bussi A R, Girelli A, Pizzocolo G, Schettino M, Negro-Vilar A
Cattedra di Clinica Medica and Chimica, University of Brescia, Italy.
J Clin Endocrinol Metab. 1993 May;76(5):1369-72. doi: 10.1210/jcem.76.5.7684394.
The aim of our study was to analyze the effects of sex and age on the GH response to galanin infusion in healthy subjects. We have studied 12 young (age, < 40 yr) nonobese healthy volunteers [6 females: age, 31.0 +/- 2.5 yr; body mass index (BMI), 21.6 +/- 0.9 kg/m2; 6 males: age, 29.2 +/- 1.4 yr; BMI, 23.3 +/- 0.4 kg/m2] and 11 old (age, > 65 yr) healthy subjects (5 females: age, 83.8 +/- 3.8 yr; BMI, 23.4 +/- 1.4 kg/m2; 6 males: age, 79.7 +/- 4.6 yr; BMI, 23.3 +/- 0.2 kg/m2). All subjects received an infusion of synthetic porcine galanin (500 micrograms, iv) in 100 mL saline from 0-45 min. Blood samples for GH measurement were drawn at -15, 0, 15, 30, 45, 60, 90, and 120 min. The GH peaks after galanin treatment in young females (11.9 +/- 2.9 micrograms/L) were significantly (P < 0.05) higher than those in the young males (5.1 +/- 1.8 micrograms/L). Old males showed significantly higher peak GH levels after galanin treatment (8.6 +/- 3.1 micrograms/L) than old females (2.4 +/- 0.6 micrograms/L). The GH peaks and areas under the curve after galanin treatment were significantly (P < 0.05) higher in young than in old females. On the contrary, no significant differences were observed after galanin treatment in young and old males. The magnitude of galanin-induced GH secretion significantly correlated with estradiol levels in young women. Our data seem to suggest that circulating estrogen levels play a crucial permissive role in galanin-induced GH secretion in humans.
我们研究的目的是分析性别和年龄对健康受试者中甘丙肽输注后生长激素（GH）反应的影响。我们研究了12名年轻（年龄<40岁）非肥胖健康志愿者[6名女性：年龄31.0±2.5岁；体重指数（BMI）21.6±0.9kg/m²；6名男性：年龄29.2±1.4岁；BMI 23.3±0.4kg/m²]和11名老年（年龄>65岁）健康受试者（5名女性：年龄83.8±3.8岁；BMI 23.4±1.4kg/m²；6名男性：年龄79.7±4.6岁；BMI 23.3±0.2kg/m²）。所有受试者在0至45分钟内接受100mL盐水中合成猪甘丙肽（500微克，静脉注射）输注。在-15、0、15、30、45、60、90和120分钟采集用于测量GH的血样。年轻女性在甘丙肽治疗后的GH峰值（11.9±2.9微克/升）显著高于年轻男性（5.1±1.8微克/升）（P<0.05）。老年男性在甘丙肽治疗后的GH峰值水平（8.6±3.1微克/升）显著高于老年女性（2.4±0.6微克/升）。年轻女性在甘丙肽治疗后的GH峰值和曲线下面积显著高于老年女性（P<0.05）。相反，在年轻和老年男性中，甘丙肽治疗后未观察到显著差异。甘丙肽诱导的GH分泌量与年轻女性的雌二醇水平显著相关。我们的数据似乎表明，循环雌激素水平在人类甘丙肽诱导的GH分泌中起关键的允许作用。
