水疱性口炎病毒上的细胞毒性T细胞保护性表位比辅助性T细胞表位少。
Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus.
作者信息
Kündig T M, Castelmur I, Bachmann M F, Abraham D, Binder D, Hengartner H, Zinkernagel R M
机构信息
Institute of Experimental Immunology, University of Zürich, Switzerland.
出版信息
J Virol. 1993 Jun;67(6):3680-3. doi: 10.1128/JVI.67.6.3680-3683.1993.
Abstract
Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes.
摘要
监测了不同小鼠品系中的细胞毒性T淋巴细胞（CTL）和辅助性T细胞反应。针对水疱性口炎病毒三种蛋白的保护性CTL反应性与H-2相关，并且仅在15种测试组合中的一半中可诱导（五种H-2单倍型中的每一种与三种病毒蛋白中的每一种组合），而生物学上相关的辅助性T细胞反应在所有组合中均可诱导。这表明水疱性口炎病毒表现出的辅助性T细胞表位比CTL表位更多。
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