Masuda K, Nagata S, Hirano K, Takagishi Y, Hirai H
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Microbiol Immunol. 1993;37(2):165-7. doi: 10.1111/j.1348-0421.1993.tb03195.x.
This paper describes an attempt to effectively induce antibody-dependent cell-mediated cytotoxicity (ADCC) in nude mice. A monoclonal antibody against alpha-fetoprotein, 80G, coadministered with spleen cells from other nude mice bearing HuH-7N (xenograft of human hepatoma cell line, HuH-7) significantly suppressed the growth of HuH-7N as compared to treatment with 80G alone. 80G with spleen cells from normal nude mice also had some suppressive effect. In contrast, no effect was observed with each spleen cells alone as well as 80G alone. These results suggest that further supply of effector cells could enhance ADCC activity in nude mice.
本文描述了一项在裸鼠中有效诱导抗体依赖性细胞介导的细胞毒性（ADCC）的尝试。一种抗甲胎蛋白单克隆抗体80G，与来自其他携带HuH-7N（人肝癌细胞系HuH-7的异种移植）的裸鼠的脾细胞共同给药，与单独使用80G治疗相比，显著抑制了HuH-7N的生长。80G与正常裸鼠的脾细胞联合使用也有一定的抑制作用。相比之下，单独使用脾细胞以及单独使用80G均未观察到效果。这些结果表明，进一步提供效应细胞可增强裸鼠中的ADCC活性。
