Gordon M N
Department of Pharmacology and Therapeutics, University of South Florida College of Medicine.
J Fla Med Assoc. 1993 Apr;80(4):267-70.
Although the brain has been traditionally viewed as immunologically privileged, it is now clear that the brain is surveyed by T lymphocytes, that resident brain microglia express immune-related antigens and can function as antigen-presenting cells, and that glial cells can synthesize and respond to cytokines, once viewed as immune system specific regulators. Alzheimer's disease is associated with increased expression of several immune-related markers in brain, including MHC class II antigens, complement factors and their receptors, and acute-phase proteins. Preliminary epidemiological evidence suggests that patients on long-term anti-inflammatory drug therapy for rheumatoid arthritis have an unexpectedly low incidence of Alzheimer's disease.
尽管传统上认为大脑具有免疫特权，但现在很清楚，大脑受到T淋巴细胞的监测，驻留的脑小胶质细胞表达免疫相关抗原并可作为抗原呈递细胞发挥作用，而且神经胶质细胞能够合成细胞因子并对其作出反应，而细胞因子曾被视为免疫系统的特异性调节因子。阿尔茨海默病与大脑中几种免疫相关标志物的表达增加有关，包括MHC II类抗原、补体因子及其受体，以及急性期蛋白。初步的流行病学证据表明，长期接受类风湿关节炎抗炎药物治疗的患者患阿尔茨海默病的几率出奇地低。
