Piomelli D
Institut National de la Santé et de la Recherche Médicale, Paris, France.
Curr Opin Cell Biol. 1993 Apr;5(2):274-80. doi: 10.1016/0955-0674(93)90116-8.
Important advances have recently been made in our understanding of the arachidonic acid cascade. The molecular characterization of different forms of phospholipase A2 indicates that multiple pathways are involved in the release of arachidonic acid evoked by physiological or pathological stimuli. Moreover, studies on the expression of enzymes that metabolize arachidonic acid reveal the potential participation of the eicosanoids in central aspects of cell regulation, such as control of mitogenesis. Finally, cloning of the first eicosanoid receptors is a major step towards elucidating the diverse cellular functions exerted by these bioactive lipids.
最近，我们对花生四烯酸级联反应的理解取得了重要进展。不同形式的磷脂酶A2的分子特征表明，生理或病理刺激引发的花生四烯酸释放涉及多种途径。此外，对代谢花生四烯酸的酶表达的研究揭示了类花生酸在细胞调节核心方面的潜在参与，如对有丝分裂的控制。最后，首个类花生酸受体的克隆是阐明这些生物活性脂质发挥的多种细胞功能的重要一步。
