Remr J
Psychiatrické oddĕlení, Praha.
Cesk Psychiatr. 1993 Jan;89(1):18-9.
The author presents some comments of an open study on clinical evaluation of risperidone. Except for the diminuation of the manifest psychotic symptoms sedative and extrapyramidal side-effects appeared, which decreased during further medication, as well as the tachycardia. The exclusion of the restless patient at the very beginning of the study was the negative result of the wash-out interval. As a maintenance therapy 1-2 mg daily dose of respiridone was enough. Further follow-up is useful after one year medication to study the longterm effect of the therapy. The main purpose of the paper is to state ten practical problems which should be taken into consideration.
作者介绍了一项关于利培酮临床评估的开放性研究的一些评论。除了明显的精神病症状有所减轻外，还出现了镇静和锥体外系副作用，这些副作用在后续用药过程中有所减少，还有心动过速。在研究一开始就排除坐立不安的患者是洗脱期的负面结果。作为维持治疗，每日1 - 2毫克的利培酮剂量就足够了。用药一年后进行进一步随访有助于研究该疗法的长期效果。本文的主要目的是阐述十个需要考虑的实际问题。
