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负协同效应可能解释了ATP敏感性钾通道的浓度-反应曲线的平坦现象。

Negative cooperativity may explain flat concentration-response curves of ATP-sensitive potassium channels.

作者信息

Hehl S, Neumcke B

机构信息

I. Physiologisches Institut, Universität des Saarlandes, Homburg/Saar, Germany.

出版信息

Eur Biophys J. 1993;22(1):1-4. doi: 10.1007/BF00205806.

DOI:10.1007/BF00205806
PMID:7685688
Abstract

Blockage of ATP-sensitive K+ channels by various drugs has been reported to exhibit a weak concentration dependence with Hill coefficients below unity. This phenomenon is interpreted by a negative cooperativity between K+ channels whereby drug binding to one channel lowers the drug affinities of neighbouring channels. Results are presented for a dimeric and a tetrameric channel model and compared with published experimental data.

摘要

据报道，各种药物对ATP敏感性钾通道的阻断表现出较弱的浓度依赖性，希尔系数低于1。这种现象被解释为钾通道之间的负协同作用，即药物与一个通道的结合会降低相邻通道的药物亲和力。给出了二聚体和四聚体通道模型的结果，并与已发表的实验数据进行了比较。

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本文引用的文献

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脑代谢物犬尿喹啉酸抑制α7烟碱型受体活性并增加非α7烟碱型受体表达：生理病理学意义
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Cytosolic ADP enhances the sensitivity to tolbutamide of ATP-dependent K+ channels from pancreatic B-cells.胞质中的二磷酸腺苷（ADP）增强了胰腺β细胞中ATP依赖性钾通道对甲苯磺丁脲的敏感性。
FEBS Lett. 1988 Nov 7;239(2):241-4. doi: 10.1016/0014-5793(88)80925-6.
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Low-conductance states of K+ channels in adult mouse skeletal muscle.成年小鼠骨骼肌中钾离子通道的低电导状态
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Purified skeletal muscle 1,4-dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers.纯化的骨骼肌1,4-二氢吡啶受体在平面双层膜中形成磷酸化依赖性寡聚钙通道。
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4290-4. doi: 10.1073/pnas.85.12.4290.
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Conductance properties and voltage dependence of an anion channel in amphibian skeletal muscle.
Pflugers Arch. 1987 Dec;410(6):641-7. doi: 10.1007/BF00581325.
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The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP.大鼠胰腺β细胞中钾通道的ATP敏感性受ADP调节。
FEBS Lett. 1986 Nov 10;208(1):63-6. doi: 10.1016/0014-5793(86)81533-2.
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