IgA 冷凝集素识别糖蛋白上表达的 Pr 和 Sa 抗原。

IgA cold agglutinins recognize Pr and Sa antigens expressed on glycophorins.

作者信息

Roelcke D, Hack H, Kreft H, MacDonald B, Pereira A, Habibi B

机构信息

Institute for Immunology, Blood Bank, University of Heidelberg, Germany.

出版信息

Transfusion. 1993 Jun;33(6):472-5. doi: 10.1046/j.1537-2995.1993.33693296808.x.

DOI:10.1046/j.1537-2995.1993.33693296808.x

PMID:7685930

Abstract

Three cases of IgA kappa cold agglutinins (CAs) were studied. One had anti-Pr1 specificity, one had anti-Pra, and one had anti-Sa. The CAs recognize O-glycans of glycophorins. The findings supplement previous data on anti-Pr1 specificities of four IgA kappa CAs. Because all IgA kappa CAs described recognize O-glycans of glycophorins, a close association between the CA IgA isotype and specificities for O-glycans becomes apparent. It is unlikely, however, that the striking association reflects interrelations between IgA CA structure and specificity, because anti-Sa specificity and all anti-Pr subspecificities were originally defined with IgM CAs.

摘要

对3例IgA κ型冷凝集素（CA）进行了研究。1例具有抗Pr1特异性，1例具有抗Pra特异性，1例具有抗Sa特异性。这些冷凝集素识别血型糖蛋白的O-聚糖。这些发现补充了先前关于4例IgA κ型CA抗Pr1特异性的数据。由于所描述的所有IgA κ型CA都识别血型糖蛋白的O-聚糖，因此CA IgA同种型与O-聚糖特异性之间的密切关联变得明显。然而，这种显著关联不太可能反映IgA CA结构与特异性之间的相互关系，因为抗Sa特异性和所有抗Pr亚特异性最初是用IgM CA定义的。