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基于FK506免疫抑制的肝移植后原发性胆汁性肝硬化的复发

Recurrence of primary biliary cirrhosis after liver transplantation following FK506-based immunosuppression.

作者信息

Wong P Y, Portmann B, O'Grady J G, Devlin J J, Hegarty J E, Tan K C, Williams R

机构信息

Institute of Liver Studies, King's College Hospital and School of Medicine and Dentistry, London, United Kingdom.

出版信息

J Hepatol. 1993 Mar;17(3):284-7. doi: 10.1016/s0168-8278(05)80206-5.

DOI:10.1016/s0168-8278(05)80206-5
PMID:7686192
Abstract

We report two cases of recurrence of primary biliary cirrhosis (PBC) in the transplanted liver whilst maintained on a FK506-based immunosuppressive regime, the first to be described. One patient experienced symptoms in association with the development of cholestasis. In both there was a persistence of serological markers of PBC and liver histology revealed florid bile duct destruction and a granulomatous reaction.

摘要

我们报告了两例原发性胆汁性肝硬化（PBC）在移植肝中复发的病例，这是首次被描述的病例，患者在基于FK506的免疫抑制方案维持治疗期间出现复发。一名患者出现了与胆汁淤积发展相关的症状。两名患者的PBC血清学标志物持续存在，肝脏组织学显示有明显的胆管破坏和肉芽肿反应。

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