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[同种异体肾移植后纤维蛋白原裂解产物 - E在纤维蛋白尿中的表现(作者译)]

[Behavior of fibrinogen-split-product-E in fibrinuria following allogeneic kidney transplantation (author's transl)].

作者信息

Zühlke V, Hölscher M, Pernice G

出版信息

Klin Wochenschr. 1975 Aug 1;53(15):717-22. doi: 10.1007/BF01468703.

Abstract

80 urine samples from 10 kidney grafted patients were immunologically analyzed for detection of fibrin degradation products by various techniques. Split product E, which was quantitatively determined by two-dimensional immunoelectrophoresis only contributes to a minor part to fibrinuria, but increases significantly during periods of severe acute rejection also during the first 2-3 weeks, when overall fibrinuria is not a useful indicator of impending rejection. Determination of split-product E therefore seems to be a valuable diagnostic procedure.

摘要

对10例肾移植患者的80份尿液样本进行了免疫分析,采用多种技术检测纤维蛋白降解产物。仅通过二维免疫电泳定量测定的裂解产物E在纤维蛋白尿中所占比例较小,但在严重急性排斥反应期间,以及在最初2 - 3周内,当总体纤维蛋白尿并非即将发生排斥反应的有用指标时,其水平会显著升高。因此,测定裂解产物E似乎是一种有价值的诊断方法。

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