Watson S R
Dept. of Immunology, Genentech Inc., South San Francisco, CA 94080.
Agents Actions Suppl. 1993;41:103-9.
In order to perform their role as mediators of inflammation neutrophils must be able to extravasate from the blood into the surrounding tissue. The initial step in this process is the rolling of neutrophils along the endothelium and is mediated by adhesion molecules known as selectins. This review will discuss the in vitro and in vivo characterization of an L-selectin-IgG chimera. The aim of the studies being to understand the role that the selectins might play in inflammatory responses and hopefully control those that are chronic or lifethreatening.
为了发挥其作为炎症介质的作用，中性粒细胞必须能够从血液中渗出到周围组织中。这个过程的第一步是中性粒细胞沿着内皮滚动，这是由称为选择素的粘附分子介导的。本综述将讨论L-选择素-IgG嵌合体的体外和体内特性。这些研究的目的是了解选择素在炎症反应中可能发挥的作用，并有望控制那些慢性或危及生命的炎症反应。
