Fujita H
2nd Department of Internal Medicine, Kyorin University School of Medicine.
Nihon Rinsho. 1993 Jun;51(6):1643-9.
Leukocytes play some important roles in pathophysiological conditions, such as inflammation, atherosclerosis, etc. It has been known that adhesion of leukocytes to vascular endothelial cells is the initial step in these conditions. Leukocytes adhere to endothelial cells utilizing adhesion molecules, such as CD11/CD18-I CAM-1, sialyl Lewis X-ELAM-1, etc. In this paper. The structure, expression and function of ICAM-1 and ELAM-1 on the endothelium is explained. ICAM-1 is a 90 kd inducible surface glycoprotein that belongs to the immunogloblinsuperfamily. Expression of ICAM-1 on the endothelium exposed to TNF, IL-1, LPS and IFN-gamma increase. This expression peaks at about 24 hours. ICAM-1 binds to CD11a/CD18 on the surface of leukocytes and takes part in the transendothelial migration. ELAM-1 is a 115 kd inducible glycoprotein, that consists of one lectin domain, one EGF-like domain and six complement regulatory like molecules. Endothelial cells will express ELAM-1 following stimulation by TNF, IL-1 and LPS. This expression peaks at 4-6 hours, declines at 24 hours. ELAM-1 binds to sialyl Lewis X on the leukocytes and participates in the rolling phenomenon, the first step of adherence to endothelium. Clarification of the mechanism of adhesion molecules expression may facilitate the treatment and prevention of vascular diseases.
白细胞在病理生理状况中发挥着一些重要作用，如炎症、动脉粥样硬化等。众所周知，白细胞与血管内皮细胞的黏附是这些状况的起始步骤。白细胞利用黏附分子，如CD11/CD18 - 细胞间黏附分子 - 1（ICAM - 1）、唾液酸化路易斯X - 内皮细胞白细胞黏附分子 - 1（ELAM - 1）等与内皮细胞黏附。本文阐述了内皮细胞上ICAM - 1和ELAM - 1的结构、表达及功能。ICAM - 1是一种90千道尔顿的可诱导表面糖蛋白，属于免疫球蛋白超家族。暴露于肿瘤坏死因子（TNF）、白细胞介素 - 1（IL - 1）、脂多糖（LPS）和γ干扰素（IFN - γ）的内皮细胞上ICAM - 1的表达增加。这种表达在约24小时达到峰值。ICAM - 1与白细胞表面的CD11a/CD18结合并参与跨内皮迁移。ELAM - 1是一种115千道尔顿可诱导糖蛋白，由一个凝集素结构域、一个表皮生长因子（EGF）样结构域和六个补体调节样分子组成。内皮细胞在受到TNF、IL - 1和LPS刺激后会表达ELAM - 1。这种表达在4 - 6小时达到峰值，在24小时下降。ELAM - 1与白细胞上的唾液酸化路易斯X结合并参与滚动现象，即黏附于内皮的第一步。阐明黏附分子表达机制可能有助于血管疾病的治疗和预防。
