胍乙啶对创伤后营养障碍性疼痛自然病程的影响。
Effect of guanethidine on the natural history of post-traumatic algodystrophy.
作者信息
Field J, Atkins R M
机构信息
University Department of Orthopaedics, Bristol Royal Infirmary, United Kingdom.
出版信息
Ann Rheum Dis. 1993 Jun;52(6):467-9. doi: 10.1136/ard.52.6.467.
OBJECTIVES
To determine the effect of intravenous regional guanethidine on post-traumatic algodystrophy.
METHODS
Ten of 20 consecutive patients with algodystrophy after Colles' fracture were treated with serial intravenous regional guanethidine blockades and the other 10 were treated with physiotherapy alone. Patients were assessed before and after each block and then monthly over a six month period.
RESULTS
The treated patients had subjective and objective improvements in the assessed features of algodystrophy; treatment resulted in a significant reduction in finger tenderness at five and six months.
CONCLUSIONS
Guanethidine blockade induces short term benefits in the symptoms of algodystrophy but improves finger tenderness only in the long term.
目的
确定静脉区域注射胍乙啶对创伤后营养障碍性骨萎缩的影响。
方法
20例连续性Colles骨折后发生营养障碍性骨萎缩的患者中，10例接受了系列静脉区域胍乙啶阻滞治疗，另外10例仅接受物理治疗。在每次阻滞前后对患者进行评估，然后在六个月的时间里每月评估一次。
结果
接受治疗的患者在营养障碍性骨萎缩的评估特征方面有主观和客观的改善；治疗导致五六个月时手指压痛明显减轻。
结论
胍乙啶阻滞在短期内可改善营养障碍性骨萎缩的症状，但仅在长期内可改善手指压痛。
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