Dib J A, Cooper-Vastola S A, Meirelles R F, Bagchi S, Caboclo J L, Holm C, Eisenberg M M
Department of Surgery, Lenox Hill Hospital, New York, New York 10021.
Am J Surg. 1993 Jul;166(1):18-23. doi: 10.1016/s0002-9610(05)80575-6.
The effects of intravenous ethanol and ethanol plus furosemide on pancreatic capillary blood flow (PCBF) were investigated using a laser-Doppler flowmeter. Forty Sprague-Dawley male rats were divided into 4 groups: (1) control, (2) 80% ethanol, (3) 80% ethanol plus furosemide, and (4) furosemide. Mean arterial blood pressure and heart rate were monitored. Levels of serum amylase, calcium, electrolytes, ethanol, and furosemide (groups 3 and 4) were measured, and samples of pancreatic tissue were obtained. The ethanol and furosemide levels were statistically different (p < 0.05). PCBF significantly decreased (p < 0.05) in group 2, increased (p < 0.05) in group 3, and did not differ (p > 0.05) between groups 1 and 4. Histopathologic analysis revealed swollen acini in group 2 and sparse focal necrosis without acinar swelling in group 3. The depressant effect of ethanol on PCBF may be the result of its direct action on pancreatic cells causing edema and capillary compression rather than on primary vascular control mechanisms that adjust blood flow. Furosemide counters this effect.
使用激光多普勒血流仪研究了静脉注射乙醇以及乙醇加呋塞米对胰腺毛细血管血流量（PCBF）的影响。将40只雄性Sprague-Dawley大鼠分为4组：（1）对照组，（2）80%乙醇组，（3）80%乙醇加呋塞米组，（4）呋塞米组。监测平均动脉血压和心率。测量血清淀粉酶、钙、电解质、乙醇以及呋塞米（第3组和第4组）的水平，并获取胰腺组织样本。乙醇和呋塞米水平存在统计学差异（p < 0.05）。第2组PCBF显著降低（p < 0.05），第3组PCBF升高（p < 0.05），第1组和第4组之间无差异（p > 0.05）。组织病理学分析显示，第2组腺泡肿胀，第3组有稀疏的局灶性坏死但无腺泡肿胀。乙醇对PCBF的抑制作用可能是其直接作用于胰腺细胞导致水肿和毛细血管受压的结果，而非作用于调节血流的主要血管控制机制。呋塞米可抵消这种作用。
