Ramakrishna B, Date A, Kirubakaran C, Raghupathy P
Department of Pathology, Christian Medical College Hospital, Vellore, India.
Ann Trop Paediatr. 1993;13(2):159-63. doi: 10.1080/02724936.1993.11747640.
We report the pattern of childhood liver disease revealed by a study of 134 biopsies obtained from 128 infants and children below the age of 16 years seen in this hospital during a 3-year period. The most common histological diagnoses were neonatal hepatitis syndrome in 23, storage disorders in 11, and cirrhosis in 26 children. Less common diagnoses included Reye's syndrome in four, fatty liver in seven, granulomas in four, and chronic active hepatitis, fulminant hepatitis, congenital hepatic fibrosis and neoplasms in two children each. Miscellaneous specific diagnoses were made in 16 cases. Twenty-three per cent of the liver biopsies were non-diagnostic. The study has provided background information on the occurrence of specific histological diagnoses in liver biopsies in infants and children in this tropical region and identifies a group with cirrhosis and copper deposition which was not typical of either Indian childhood cirrhosis or Wilson's disease.
我们报告了一项对134份活检样本的研究揭示的儿童肝病模式，这些活检样本取自本院在3年期间收治的128名16岁以下婴幼儿及儿童。最常见的组织学诊断为23例新生儿肝炎综合征、11例贮积症和26例肝硬化。较少见的诊断包括4例瑞氏综合征、7例脂肪肝、4例肉芽肿，以及各2例慢性活动性肝炎、暴发性肝炎、先天性肝纤维化和肿瘤。另有16例做出了其他特定诊断。23%的肝活检未能得出诊断结果。该研究提供了有关这个热带地区婴幼儿及儿童肝活检中特定组织学诊断发生率的背景信息，并识别出一组伴有肝硬化和铜沉积的病例，这既非典型的印度儿童肝硬化，也非威尔逊病。
