Recombinant cDNA encapsulation in small liposomes with hepatocyte access ability.
作者信息
Aliño S F, Bobadilla M, Unda F J, Garcia-Sanz M, Hilario E, Lejarreta M
机构信息
Department of Pharmacology, Faculty of Medicine and Dentistry, University of Valencia, Spain.
出版信息
J Microencapsul. 1993 Apr-Jun;10(2):163-70. doi: 10.3109/02652049309104382.
PMID:7687286
Abstract
Liposomal encapsulation efficiency of a recombinant cDNA was studied by several procedures. We observed that supernatant fraction of ultracentrifuged liposomes prepared by extrusion through polycarbonate filters of 400 nm pore size yielded a very homogeneous suspension of small (50 nm diameter) unilamellar liposomes with highest DNA/lipid ratio and great ability to access to hepatocytes.
摘要
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