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爱丁堡颈动脉内膜切除术的趋势及当前实践审计(1975 - 1990年)

An audit of trends and current practice of carotid endarterectomy in Edinburgh (1975-1990).

作者信息

John T G, Naylor A R, Howlett J, Gillespie I, Jenkins A M, Ruckley C V

机构信息

Department of Vascular Surgery, Royal Infirmary, Edinburgh, UK.

出版信息

J R Coll Surg Edinb. 1993 Jun;38(3):138-41.

PMID:7687672
Abstract

Changes in the patient population and trends in management were studied for 260 consecutive carotid endarterectomies performed during the periods 1975-1982 and 1983-1990. A 43% increase was observed in the number of operations (from 107 to 153), an 81% increase taking into account patients randomized to medical treatment in the European Carotid Surgery Trial. There were significant reductions in patients continuing to smoke (79 to 60%, P = 0.001), in those with systolic hypertension (21 to 11%, P = 0.018) and diastolic hypertension (26 to 12%, P = 0.002), and in those with asymptomatic carotid lesions (8 to 2%, P = 0.031). There were significant increases in the proportion of patients with strokes presenting with a residual neurological deficit (40 to 66%, P = 0.024), and in those with ocular symptoms (30 to 50%, P = 0.001) and with stenoses greater than 50% (58 to 71%, P = 0.018). This study suggests a trend for a higher risk population with more severe carotid disease. In the light of results of clinical trials, further evolution of patient selection is likely to occur and should be taken into account when evaluating the risk of carotid endarterectomy.

摘要

对1975 - 1982年和1983 - 1990年期间连续进行的260例颈动脉内膜切除术患者群体的变化和治疗趋势进行了研究。手术数量增加了43%(从107例增至153例),若将欧洲颈动脉外科试验中随机接受药物治疗的患者计算在内,则增加了81%。持续吸烟的患者显著减少(从79%降至60%,P = 0.001),收缩期高血压患者(从21%降至11%,P = 0.018)和舒张期高血压患者(从26%降至12%,P = 0.002),以及无症状性颈动脉病变患者(从8%降至2%,P = 0.031)均显著减少。出现残留神经功能缺损的中风患者比例(从40%增至66%,P = 0.024)、有眼部症状的患者比例(从30%增至50%,P = 0.001)以及狭窄大于50%的患者比例(从58%增至71%,P = 0.018)均显著增加。这项研究表明患者群体有向颈动脉疾病更严重的高风险趋势发展。鉴于临床试验结果,患者选择可能会进一步演变,在评估颈动脉内膜切除术风险时应予以考虑。

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