Sonea I M, Bowker R M, Broadstone R V, Robinson N E
Department of Anatomy, Michigan State University, East Lansing 48824.
Res Vet Sci. 1993 May;54(3):335-9. doi: 10.1016/0034-5288(93)90131-x.
The tone of respiratory smooth muscle is largely determined by the input from autonomic nerves. The distribution of adrenergic and selected nonadrenergic, non-cholinergic (NANC) nerves in the normal equine trachealis muscle was investigated using immunohistochemistry. The smooth muscle of the trachealis was found to contain numerous nerves immunoreactive for an enzymatic marker of adrenergic nerves, as well as many nerves immunoreactive for a putative NANC neurotransmitter, peptide histidine isoleucine, a potent bronchodilator. The tissue surrounding the respiratory smooth muscle contained numerous nerves immunoreactive for the neuropeptides substance P and calcitonin gene-related peptide, which can cause marked vasodilation and bronchoconstriction. The complex innervation of the equine trachea should be kept in mind when interpreting the results of physiological experiments.
呼吸平滑肌的张力很大程度上取决于自主神经的输入。采用免疫组织化学方法研究了正常马气管平滑肌中肾上腺素能神经以及部分非肾上腺素能、非胆碱能（NANC）神经的分布。结果发现，气管平滑肌含有大量对肾上腺素能神经的一种酶标记物呈免疫反应的神经，以及许多对一种假定的NANC神经递质——肽组氨酸异亮氨酸（一种强效支气管扩张剂）呈免疫反应的神经。呼吸平滑肌周围的组织含有大量对神经肽P物质和降钙素基因相关肽呈免疫反应的神经，这些神经可引起显著的血管舒张和支气管收缩。在解释生理学实验结果时，应考虑到马气管复杂的神经支配情况。
