Zhang Y, Schlegelberger B, Plendl H, Sonnen R, Kuse R, Feller A C, Grote W
Institute of Human Genetics, University of Kiel, Germany.
Genes Chromosomes Cancer. 1993 Jul;7(3):165-8. doi: 10.1002/gcc.2870070309.
A clone with an unbalanced translocation t(8;14)(p11;q31), resulting in deletion of the distal part of the long arm of chromosome 14, 14q31 --> 14qter, was detected in a case of Piringer's lymphadenitis. Histopathologically no atypical cells or other signs of malignant lymphoma were found. Southern blot analyses showed no rearrangement of the immunoglobulin heavy chain gene (IGH) or the T-cell receptor gamma chain (TCRG) gene. The case exemplifies that the detection of a chromosomally aberrant clone does not necessarily prove that a lymphoproliferative process is malignant.
在一例皮林格淋巴结炎病例中检测到一个具有不平衡易位t(8;14)(p11;q31)的克隆，该易位导致14号染色体长臂远端部分缺失，即14q31→14qter。组织病理学检查未发现非典型细胞或恶性淋巴瘤的其他迹象。Southern印迹分析显示免疫球蛋白重链基因（IGH）或T细胞受体γ链（TCRG）基因无重排。该病例表明，检测到染色体异常克隆并不一定证明淋巴细胞增殖过程是恶性的。
