Begley C G
Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Victoria.
Med J Malaysia. 1993 Mar;48(1):3-8.
The Colony Stimulating Factors (CSFs) are a family of haemopoietic hormones that likely share a common ancestral origin and stimulate white blood cell development. They display unique but overlapping biological functions and stimulate the survival, proliferation, differentiation and functional activation of granulocytes and monocytes/macrophages and their precursor cells in vitro and in vivo. Each hormone has been purified and produced in active recombinant form. Recombinant G-CSF and GM-CSF are now being used around the world in a variety of clinical situations (e.g., in conjunction with chemotherapy and bone marrow transplantation) to promote the formation and function of these leukocytes. These molecules are among the first of a new generation of biological agents that will impact enormously on clinical medicine.
集落刺激因子（CSFs）是一类造血激素，它们可能有着共同的祖先起源，并刺激白细胞的发育。它们具有独特但又相互重叠的生物学功能，在体外和体内均可刺激粒细胞、单核细胞/巨噬细胞及其前体细胞的存活、增殖、分化和功能激活。每种激素均已被纯化并以活性重组形式生产出来。重组人粒细胞集落刺激因子（G-CSF）和重组人粒细胞巨噬细胞集落刺激因子（GM-CSF）目前正在全球范围内用于多种临床情况（例如，与化疗和骨髓移植联合使用），以促进这些白细胞的形成和功能。这些分子是新一代生物制剂中的首批成员，将对临床医学产生巨大影响。
