Degos F
Service d'hépatologie, hôpital Beaujon, Clichy.
Rev Prat. 1993 Mar 1;43(5):569-73.
Interferon is presently the treatment of chronic liver infection with hepatitis B and C viruses. Major advances have been made in the field of hepatitis B virus with interferon, which is able to clear viral replication in 30 to 40% of the cases. Interferon is also efficient in the treatment of hepatitis C chronic infections, normalizing transaminase activity in 60 to 70% of the patients, but a relapse is observed after interruption of treatment, and a sustained remission is obtained in only 20% of the cases. These results demonstrate the need for further clinical research to elucidate the precise indications of this treatment.
干扰素目前是治疗乙型和丙型肝炎病毒慢性肝感染的方法。在乙型肝炎病毒领域，使用干扰素已取得重大进展，它能够在30%至40%的病例中清除病毒复制。干扰素在治疗丙型肝炎慢性感染方面也很有效，能使60%至70%的患者转氨酶活性恢复正常，但治疗中断后会出现复发，只有20%的病例能获得持续缓解。这些结果表明需要进一步开展临床研究，以阐明这种治疗的确切适应症。
