Triebel F, Escudier B
Service d'hémato-immunologie, INSERM U 333, Institut Gustave-Roussy, Villejuif.
Rev Prat. 1993 Mar 1;43(5):580-5.
Various cytokines can be used in the treatment of solid tumours. They are factors of proliferation and/or differentiation of haematopoiesis or immunopoiesis, and they stimulate the effector cells of anti-tumoral response. The various steps in the preclinical and clinical development of a cytokine in the field of oncology are detailed, taking IL-2 as an example. The results of the clinical trials reported (essentially with INF and IL-2) are presented and discussed.
多种细胞因子可用于实体瘤的治疗。它们是造血或免疫造血增殖和/或分化的因子，并刺激抗肿瘤反应的效应细胞。以白细胞介素-2为例，详细介绍了肿瘤学领域中细胞因子临床前和临床开发的各个步骤。展示并讨论了所报道的临床试验结果（主要是干扰素和白细胞介素-2的试验结果）。
