Hasselmo M E, Bower J M
Dept of Psychology, Harvard University, Cambridge, MA 02138.
Trends Neurosci. 1993 Jun;16(6):218-22. doi: 10.1016/0166-2236(93)90159-j.
Acetylcholine may set the dynamics of cortical networks to those appropriate for learning of new information, while decreased cholinergic modulation may set the appropriate dynamics for recall. In slice preparations of the olfactory cortex, acetylcholine selectively suppresses intrinsic but not afferent fiber synaptic transmission, while decreasing the adaptation of pyramidal cells. In biologically realistic models of this region, the selective suppression of synaptic transmission prevents recall of previously learned memories from interfering with the learning of new memories, while the decrease in adaptation enhances the response to afferent input and the modification of synapses. This theoretical framework may serve to guide future studies linking neuromodulators to cortical memory function.
乙酰胆碱可能会将皮质网络的动力学设定为适合学习新信息的状态，而胆碱能调制的减少可能会为回忆设定适当的动力学。在嗅觉皮质的脑片制备中，乙酰胆碱选择性地抑制内在而非传入纤维的突触传递，同时减少锥体细胞的适应性。在该区域的生物逼真模型中，突触传递的选择性抑制可防止先前学习的记忆干扰新记忆的学习，而适应性的降低则增强了对传入输入的反应和突触的修饰。这一理论框架可能有助于指导未来将神经调质与皮质记忆功能联系起来的研究。
