β-蛋白激酶C而非α-蛋白激酶C可能参与3T3-L1细胞向脂肪细胞的分化过程。
Possible involvement of beta-PKC rather than that of alpha-PKC in differentiation of 3T3-L1 cells to adipocytes.
作者信息
Ueda H, Ishida Y, Taniguchi H
机构信息
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
出版信息
Eur J Clin Invest. 1993 Jun;23(6):382-4. doi: 10.1111/j.1365-2362.1993.tb02040.x.
The change of subspecies of protein kinase C (PKC) was studied in 3T3-L1 cells in terms of their differentiation to adipocytes. 3T3-L1 cells feasible to differentiate to adipocytes by exposure to 3-isobutyl-1-methylxanthine (IBMX) and dexamethasone had both alpha- and beta-PKC. However, 3T3-L1 cells unfurnished with such feasibility had only alpha-PKC. alpha-PKC, therefore, seems to be more deeply involved in differentiation of 3T3-L1 cells to adipocytes than alpha-PKC.
就蛋白激酶C（PKC）的亚型变化而言，我们在3T3-L1细胞向脂肪细胞分化的过程中对其进行了研究。通过暴露于3-异丁基-1-甲基黄嘌呤（IBMX）和地塞米松而易于分化为脂肪细胞的3T3-L1细胞同时具有α-PKC和β-PKC。然而，不具备这种分化能力的3T3-L1细胞仅具有α-PKC。因此，α-PKC似乎比α-PKC更深入地参与3T3-L1细胞向脂肪细胞的分化过程。 （注：原文中出现两次alpha-PKC表述可能有误，按照逻辑这里第二个应该是beta-PKC，译文已按此逻辑翻译）
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