Sugino T, Kawaguchi T, Suzuki T
Department of Pathology, Fukushima Medical College, Japan.
Int J Cancer. 1993 Aug 19;55(1):141-7. doi: 10.1002/ijc.2910550125.
We examined the correlation between growth characteristics and the incidence of lung metastases of spontaneous mammary tumors in C3H mice. The growth pattern of the mammary tumors was composed of initial rapid growth, declining growth, and further exponential growth (re-growth). The "re-growth" was closely associated with loss of differentiation and progressive increase of the incidence of lung metastases. In addition, we observed the sequential process of blood-borne lung metastases. The findings involved (i) "passive" intravasation: carcinoma nests encased in newly formed endothelial cells are released into sinusoidal vessels within primary tumors; (ii) "mechanical" arrest and proliferation of multicellular tumor emboli in pulmonary arterioles; (iii) "active" extravasation: carcinoma cells rushed out to the lung parenchyma through the arteriolar walls ruptured by initial minimal penetration of carcinoma cells and intravascular pressure. The results indicate a stable progression in the natural history of C3H mouse mammary carcinomas characterized by growth characteristics, the incidence of lung metastases, and histological change generating a poorly differentiated clone which can successfully complete a sequential process of blood-borne lung metastasis.
我们研究了C3H小鼠自发性乳腺肿瘤的生长特征与肺转移发生率之间的相关性。乳腺肿瘤的生长模式由最初的快速生长、生长减缓以及进一步的指数生长（再生长）组成。“再生长”与分化丧失以及肺转移发生率的逐渐增加密切相关。此外，我们观察了血行性肺转移的连续过程。研究结果包括：（i）“被动”血管内侵入：包裹在新形成的内皮细胞中的癌巢被释放到原发肿瘤内的窦状血管中；（ii）多细胞肿瘤栓子在肺小动脉中的“机械性”滞留和增殖；（iii）“主动”血管外渗：癌细胞通过最初由癌细胞的微小穿透和血管内压力导致的小动脉壁破裂而冲向肺实质。结果表明，C3H小鼠乳腺癌自然史呈现出稳定进展，其特征包括生长特征、肺转移发生率以及组织学变化，这些变化产生了一个低分化克隆，该克隆能够成功完成血行性肺转移的连续过程。
