[The effect of recombinant interleukin-1 beta on the chemotactic activity of neutrophilic leukocytes].

The role of interleukin-1 in the activation of neutrophils, the main effects of inflammatory reaction, is still unclear. This study has demonstrated that the recombinant preparation interleukin-1 beta (IL-1 beta) which the authors have obtained fails to produce a direct action on the locomotor functions of neutrophils. At the same time, injection of IL-1 beta in mice leads to neutrophilic migration to the injection site and their efflux into peripheral blood. These findings confirm the assumption that interleukin-1 produces a mediator effect on neutrophilic chemotaxis.