Kremer B, Tallaksen-Greene S J, Albin R L
Department of Medical Genetics, University of British Columbia, Canada.
Neurology. 1993 Aug;43(8):1593-5. doi: 10.1212/wnl.43.8.1593.
The excitatory amino acid (EAA) hypothesis of neuronal loss in Huntington's disease predicts that structures that show neuronal loss and gliosis will contain receptor-bearing neurons. In accordance with this hypothesis, the hypothalamic lateral tuberal nucleus, severely affected in Huntington's disease, showed a high density of NMDA and AMPA binding sites in four normal subjects.
亨廷顿病神经元丢失的兴奋性氨基酸（EAA）假说预测，显示神经元丢失和神经胶质增生的结构将包含有受体的神经元。根据这一假说，在亨廷顿病中受到严重影响的下丘脑外侧结节核，在四名正常受试者中显示出高密度的NMDA和AMPA结合位点。
