Study of tyrosine hydroxylase and neuropeptidergic innervation of the human obstructed pelveoureteral junction in four different patients.

Tyrosine hydroxylase and neuropeptidergic innervations of the obstructed pelveoureteral junctions of four different patients were investigated by immunohistochemical methods. A dense innervation of tyrosine hydroxylase- and neuropeptide Y-nerves was found especially in the pelveoureteral junction, which was congenitally obstructed, compared to others found later (13- and 23-year old females). Also quite numerous vasoactive intestinal polypeptide-nerves were seen as well as some calcitonin gene-related peptide-, galanin- and substance P-nerves in the muscular layer of ureter. The innervation pattern of the obstructed pelveoureteral junction of the horseshoe kidney was found to be normal.