Gali H U, Perchellet E M, Gao X M, Bottari V, Perchellet J P
Anti-Cancer Drug Laboratory, Kansas State University, Manhattan 66506-4901.
Anticancer Res. 1993 Jul-Aug;13(4):915-22.
Sumach leaf, Aleppo gall, Tara pod and commercial tannic acids (TAs) were tested topically for their ability to inhibit the biochemical and biological effects of 12-0-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis in vivo. These TAs all inhibit to various degrees ornithine decarboxylase (ODC) induction, hydroperoxide (HPx) production and the sequential stimulation of RNA, protein and DNA synthesis linked to TPA promotion. When applied before each promotion treatment, these TAs all inhibit complete tumor promotion by TPA. Sumach leaf TA is the most effective. TAs applied 24h after TPA inhibit HPx production but not tumor promotion, since ODC activity and DNA synthesis have already been stimulated. However, these TA post-treatments enhance the antioxidant and antitumor-promoting effects of TA pretreatments. TAs inhibit the 2nd rather than the 1st stage of tumor promotion. Plant TAs, therefore, may be valuable against tumor propagation but their efficacy may vary considerably depending on their origin.
对漆树叶、没食子、塔拉豆荚和市售单宁酸（TAs）进行了局部测试，以评估它们在体内抑制小鼠表皮中12 - 0 - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）的生化和生物学效应的能力。这些单宁酸均不同程度地抑制鸟氨酸脱羧酶（ODC）的诱导、过氧化氢（HPx）的产生以及与TPA促进相关的RNA、蛋白质和DNA合成的顺序刺激。在每次促进治疗前应用时，这些单宁酸均能抑制TPA的完全肿瘤促进作用。漆树叶单宁酸最为有效。在TPA后24小时应用单宁酸可抑制HPx的产生，但不能抑制肿瘤促进作用，因为ODC活性和DNA合成已经被刺激。然而，这些单宁酸后处理增强了单宁酸预处理的抗氧化和抗肿瘤促进作用。单宁酸抑制肿瘤促进的第二阶段而非第一阶段。因此，植物单宁酸可能对肿瘤增殖有价值，但其功效可能因其来源而有很大差异。
