Yamamoto H
Department of Immunology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Crit Rev Immunol. 1993;13(2):151-61.
The diversification of the receptors of B and T lymphocytes is determined by stepwise gene rearrangement of the V genes and the D-J segment. However, this repertoire is not yet selected within the host environment and thus is referred to as the potential repertoire. The repertoire of the peripheral mature B and T-lymphocytes is distorted and selected from the potential repertoire by various auto- and foreign antigens in the host environment and is referred to as the available repertoire. It is well documented that the peripheral T-lymphocyte repertoire is first selected in the thymus to delete or inactivate self-reactive clones. Moreover, extensive studies done during the last decade suggest that the B- and T-lymphocyte repertoires are significantly influenced by the host immunoglobulin idiotype repertoire. In this review, the role of immunoglobulin idiotypes in the selection of the B- and T-lymphocyte repertoires is discussed.
B淋巴细胞和T淋巴细胞受体的多样化是由V基因和D-J片段的逐步基因重排决定的。然而，这种库尚未在宿主环境中进行选择，因此被称为潜在库。外周成熟B淋巴细胞和T淋巴细胞的库在宿主环境中会受到各种自身抗原和外来抗原的影响而发生扭曲，并从潜在库中进行选择，这被称为可用库。有充分的文献记载，外周T淋巴细胞库首先在胸腺中进行选择，以删除或使自身反应性克隆失活。此外，过去十年中进行的大量研究表明，B淋巴细胞和T淋巴细胞库受到宿主免疫球蛋白独特型库的显著影响。在这篇综述中，将讨论免疫球蛋白独特型在B淋巴细胞和T淋巴细胞库选择中的作用。
