Lopes P, Blot P, Breart G, Thin J, Le Houezec R, Sureau C
Nouv Presse Med. 1976 Feb 14;5(7):403-6.
Induction of labor was performed in 65 patients by intravenous infusion of PgF2alpha. 55 patients were near term and induction made electively. 5 cases failed. No correlation was found between the stade of the cervix and the probability of success nor the length of the induction time. PgF2alpha induced labor needs to be closely monitored (electronical pumps and monitoring) because of the risk of hypertonus. With such a technique the side effects are minimal and no undesirable consequences were observed concerning either the mother or the child. During the course of this investigation a study was performed for the first time of the electrical activity of the human myometrium subjected to PgF2alpha stimulation. (26 recordings through the extra-amniotic intrauterine technique). The pattern of this activity is quite similar to spontaneously occuring alectrical activity.
通过静脉输注前列腺素F2α对65例患者进行引产。55例患者已接近足月,引产为选择性进行。5例引产失败。未发现宫颈成熟度与成功概率及引产时间长短之间存在相关性。由于存在子宫收缩过强的风险,前列腺素F2α引产需要密切监测(电子泵及监测)。采用这种技术,副作用极小,未观察到对母亲或胎儿有任何不良后果。在本研究过程中,首次对接受前列腺素F2α刺激的人子宫肌层的电活动进行了研究(通过羊膜外子宫内技术进行了26次记录)。这种活动模式与自发发生的电活动非常相似。