Sun D, Archibald D W, Sauk J J
Department of Pathology, School of Dentistry, University of Maryland, Baltimore 21201.
Res Virol. 1993 May-Jun;144(3):185-91. doi: 10.1016/s0923-2516(06)80028-2.
Temperature elevation constitutes a beneficial component of the host defence against viral pathogens. However, heat treatment may be detrimental to HTLV-I-infected cells by increasing virion and oncoprotein production. We investigated the effects of thermal elevation on the in vitro replication of HTLV-I (human T-cell leukaemia/lymphoma virus type I) in MT-2 cells, an HTLV-I-transformed lymphoid cell line. We found that HTLV-I replication in MT-2 cells was markedly increased as demonstrated by a nearly 2-fold increase in detection of viral p24 antigen and a 20-fold increase in reverse transcriptase activity during up to 5 h of heat treatment at 42 degrees C. The results suggest that physiologic thermal elevations may induce viral production in HTLV-I-infected individuals.
体温升高是宿主抵御病毒病原体的有益组成部分。然而，热处理可能会通过增加病毒粒子和癌蛋白的产生而对感染人嗜T淋巴细胞病毒I型（HTLV-I）的细胞有害。我们研究了温度升高对MT-2细胞（一种HTLV-I转化的淋巴样细胞系）中HTLV-I（人T细胞白血病/淋巴瘤病毒I型）体外复制的影响。我们发现，在42摄氏度进行长达5小时的热处理期间，MT-2细胞中HTLV-I的复制显著增加，这表现为病毒p24抗原检测增加近2倍，逆转录酶活性增加20倍。结果表明，生理性体温升高可能会诱导HTLV-I感染者产生病毒。
