L型钙通道调节剂对兴奋剂诱导的多动的影响。
Effect of L-type calcium channel modulators on stimulant-induced hyperactivity.
作者信息
Moore N A, Rees G, Sanger G, Awere S
机构信息
Lilly Research Centre, Eli Lilly & Co., Windlesham, Surrey, U.K.
出版信息
Neuropharmacology. 1993 Jul;32(7):719-20. doi: 10.1016/0028-3908(93)90086-i.
PMID:7689709
Abstract
The present study investigated the effect of L-type calcium channel modulators on stimulant-induced locomotor activity. The L-channel activator, (+/-)BayK8644, produced a marked, long-lasting enhancement of cocaine-induced activity, while having no effect on amphetamine hyperactivity. Nicardipine reduced cocaine hyperactivity but had no effect on the amphetamine response.
摘要
本研究调查了L型钙通道调节剂对兴奋剂诱导的运动活性的影响。L通道激活剂（±）BayK8644显著且持久地增强了可卡因诱导的活性，而对苯丙胺引起的多动没有影响。尼卡地平降低了可卡因引起的多动，但对苯丙胺反应没有影响。
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