（+）-α-甲基-4-羧基苯甘氨酸（MCPG）对新生大鼠运动神经元和大鼠丘脑神经元中（1S，3R）-ACPD诱导效应的立体特异性拮抗作用。
Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones.
作者信息
Jane D E, Jones P L, Pook P C, Salt T E, Sunter D C, Watkins J C
机构信息
Department of Pharmacology, School of Medical Sciences, Bristol, U.K.
出版信息
Neuropharmacology. 1993 Jul;32(7):725-7. doi: 10.1016/0028-3908(93)90088-k.
The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD). (+)-MCPG preferentially reduced (1S,3R)-ACPD-induced responses relative to responses induced by (S)-alpha-amino-3-hydorxy-5-methylisoxazole-4-propionic acid (AMPA) and N-methyl-D-aspartate (NMDA).
α-甲基-4-羧基苯甘氨酸（MCPG）的（+）-对映体可立体选择性地拮抗新生大鼠运动神经元的去极化以及由特异性代谢型谷氨酸受体激动剂（1S，3R）-1-氨基环戊烷-1，3-二羧酸（ACPD）诱导的大鼠丘脑神经元兴奋。相对于由（S）-α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）和N-甲基-D-天冬氨酸（NMDA）诱导的反应，（+）-MCPG优先降低（1S，3R）-ACPD诱导的反应。
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