嗅神经横断可诱导小鼠嗅上皮中神经生长因子受体的表达。

Transection of the olfactory nerves induces expression of nerve growth factor receptor in mouse olfactory epithelium.

作者信息

Miwa T, Moriizumi T, Sakashita H, Kimura Y, Donjo T, Furukawa M

机构信息

Department of Otorhinolaryngology, School of Medicine, Kanazawa University, Japan.

出版信息

Neurosci Lett. 1993 May 28;155(1):96-8. doi: 10.1016/0304-3940(93)90681-a.

DOI:10.1016/0304-3940(93)90681-a

PMID:7689719

Abstract

Expression of nerve growth factor receptor (NGFR) was found in the mouse olfactory epithelium after olfactory nerve transection, although no immunoreactivity to NGFR was detectable in the olfactory epithelium in the control animals. After axotomy, however, NGFR-immunoreactive cells transiently appeared in the supporting cells, receptor neurons and basal cells between postoperative day 7 and 35, and thereafter disappeared by postoperative day 49. The results indicate that nerve growth factor may contribute to the regeneration of olfactory receptor neurons after olfactory nerve transection.

摘要

在嗅神经横断后，在小鼠嗅上皮中发现了神经生长因子受体（NGFR）的表达，尽管在对照动物的嗅上皮中未检测到对NGFR的免疫反应性。然而，轴突切断后，NGFR免疫反应性细胞在术后第7天至35天之间短暂出现在支持细胞、受体神经元和基底细胞中，此后在术后第49天消失。结果表明，神经生长因子可能有助于嗅神经横断后嗅受体神经元的再生。