Valldeoriola F, Graus F, Steck A J, Muñoz E, de la Fuente M, Gallart T, Ribalta T, Bombí J A, Tolosa E
Service of Neurology, Hospital Clínic i Provincial de Barcelona, Spain.
Ann Neurol. 1993 Sep;34(3):394-6. doi: 10.1002/ana.410340314.
A patient who had a polyneuropathy compatible with a chronic inflammatory demyelinating polyneuropathy and was initially negative for anti-myelin-associated glycoprotein (MAG) antibodies developed a double monoclonal gammopathy, IgM kappa and IgM lambda, two years after the diagnosis. The IgM kappa, but not the IgM lambda, exhibited strong anti-MAG antibody activity. The late appearance of the anti-MAG immunoreactivity suggests that in patients with an initial diagnosis of chronic inflammatory demyelinating polyneuropathy, the search for anti-MAG antibodies should be repeated during the course of the neuropathy.
一名患有与慢性炎症性脱髓鞘性多发性神经病相符的多发性神经病的患者，最初抗髓鞘相关糖蛋白（MAG）抗体检测为阴性，在诊断两年后出现了双克隆丙种球蛋白病，即IgM κ和IgM λ。IgM κ具有很强的抗MAG抗体活性，而IgM λ则没有。抗MAG免疫反应性的迟发表明，对于最初诊断为慢性炎症性脱髓鞘性多发性神经病的患者，在神经病病程中应重复检测抗MAG抗体。
