Morita T, Yamamoto A, Hashida M, Sezaki H
Department of Basic Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Biol Pharm Bull. 1993 Mar;16(3):259-62. doi: 10.1248/bpb.16.259.
The effects of various absorption promoters on the pulmonary absorption of drugs with different molecular weights were examined in rats. Phenol red and fluorescein isothiocyanate-labeled dextrans (FDs) with various molecular weights were used as model drugs and the absorption promoters used in this study were sodium glycocholate, sodium salicylate, ethylenediaminetetraacetic acid disodium salt (Na2-EDTA) and sodium caprate, all at a concentration of 1%. Of these absorption promoters, sodium glycocholate and sodium caprate appeared to be more effective for enhancing the pulmonary absorption of these drugs than sodium salicylate and Na2-EDTA. Furthermore, it was indicated that there is the optimal molecular weight to which each absorption promoter gives the largest enhancing effect on the pulmonary absorption of drugs.
在大鼠中研究了各种吸收促进剂对不同分子量药物肺部吸收的影响。使用酚红和不同分子量的异硫氰酸荧光素标记葡聚糖（FDs）作为模型药物，本研究中使用的吸收促进剂为甘氨胆酸钠、水杨酸钠、乙二胺四乙酸二钠盐（Na2-EDTA）和癸酸钠，浓度均为1%。在这些吸收促进剂中，甘氨胆酸钠和癸酸钠在增强这些药物的肺部吸收方面似乎比水杨酸钠和Na2-EDTA更有效。此外，研究表明，每种吸收促进剂对药物肺部吸收产生最大增强作用都存在一个最佳分子量。
