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Characterization of canine platelet P-selectin (CD 62) and its utility in flow cytometry platelet studies.

作者信息

Yeo E L, Gemmell C H, Sutherland D R, Sefton M V

机构信息

Department of Medicine, Toronto Hospital, University of Toronto, Ontario, Canada.

出版信息

Comp Biochem Physiol B. 1993 Jul-Aug;105(3-4):625-36. doi: 10.1016/0305-0491(93)90098-p.

DOI:10.1016/0305-0491(93)90098-p
PMID:7689939
Abstract
  1. P-selectin (PADGEM, GMP140, or CD62) a member of lectin-like adhesive proteins is expressed on the surface of activated degranulated canine platelets and is the calcium-dependent receptor for leukocyte adhesion. 2. The electrophoretic mobility of P-selectin, by Western blot analysis and immunoprecipitation from radiolabeled membranes of canine and human platelets, was similar or identical and immunocytochemical studies localized P-selectin in internal vesicles similar to the alpha granule localization in human platelets. 3. Two antibodies to human P-selectin KC4.1 and AC1.2 crossreacted with canine platelets whose surface binding, in response to agonists thrombin, calcium ionophore (A23187), phorbol esters and ADP, was similar. 4. Anti-P-selectin antibodies in conjunction with crossreacting anti-GPIIb/IIIa antibodies (A2A9, 7E3, RUU-PL7F12) enables the analysis of activated platelets, platelet-derived microparticles and platelet-leukocyte interactions in canine models by flow cytometry.
摘要

相似文献

1
Characterization of canine platelet P-selectin (CD 62) and its utility in flow cytometry platelet studies.
Comp Biochem Physiol B. 1993 Jul-Aug;105(3-4):625-36. doi: 10.1016/0305-0491(93)90098-p.
2
A fluorescence-conjugated immunobinding assay for the detection of P-selectin on platelets.一种用于检测血小板上P-选择素的荧光共轭免疫结合测定法。
J Lab Clin Med. 1994 Sep;124(3):447-54.
3
Enhancement by IL-1 beta and IFN-gamma of platelet activation: adhesion to leukocytes via GMP-140/PADGEM protein (CD62).白细胞介素-1β和γ干扰素对血小板活化的增强作用：通过GMP-140/血小板活化依赖颗粒外膜蛋白（CD62）与白细胞黏附。
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Platelet activation in whole blood by artificial surfaces: identification of platelet-derived microparticles and activated platelet binding to leukocytes as material-induced activation events.人工表面诱导全血中的血小板活化：鉴定血小板衍生微粒以及活化血小板与白细胞的结合作为材料诱导的活化事件。
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Immunocytochemical aspects of platelet membrane glycoproteins and adhesive proteins during activation.血小板膜糖蛋白和黏附蛋白在激活过程中的免疫细胞化学特征
Prog Histochem Cytochem. 1996;30(1):1-106. doi: 10.1016/s0079-6336(96)80009-x.
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PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes.血小板活化依赖性颗粒外膜蛋白：一种介导活化血小板与中性粒细胞和单核细胞相互作用的受体。
Cell. 1989 Oct 20;59(2):305-12. doi: 10.1016/0092-8674(89)90292-4.
7
A member of the selectin family (GMP-140/PADGEM) is expressed on thrombin-stimulated rat platelets in vitro.
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8
Role of P-selectin and leukocyte activation in polymorphonuclear cell adhesion to surface adherent activated platelets under physiologic shear conditions (an injury vessel wall model).在生理剪切条件下（一种损伤血管壁模型），P-选择素和白细胞活化在多形核细胞与表面黏附的活化血小板黏附中的作用。
Blood. 1994 May 1;83(9):2498-507.
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PADGEM: an adhesion receptor for leukocytes on stimulated platelets and endothelial cells.PADGEM：一种在受刺激的血小板和内皮细胞上的白细胞黏附受体。
Proc Soc Exp Biol Med. 1991 Nov;198(2):703-9. doi: 10.3181/00379727-198-43309a.
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Two sites (23-30, 76-90) on rat P-selectin mediate thrombin activated platelet-neutrophil interactions.
Comp Biochem Physiol A Physiol. 1994 Dec;109(4):881-6. doi: 10.1016/0300-9629(94)90235-6.

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