We investigated the effects of the new calcium-agonists (+/-)-Bay W 5035 and (+/-)-Bay T 5006 in comparison to (-)-S-Bay K 8644 on hemodynamics and epimyocardial perfusion in Langendorff rat hearts. 2. At equieffective inotropic concentration, vasoconstriction of coronary resistance vessels was significantly less after (+/-)-Bay W 5035 or (+/-)-Bay T 5006 than after (-)-S-Bay K 8644 application. 3. FITC-Dextran 3 elution kinetics indicated that the epimyocardial vascular volume was significantly reduced only by (-)-S-Bay K 8644. 4. Moreover, (-)-S-Bay K 8644 enhanced transcoronary exchange more markedly than (+/-)-Bay W 5035 or (+/-)-Bay T 5006, reflecting the differences in coronary constrictor activity. 5. We conclude that in comparison to (-)-S-Bay K 8644 the relation between inotropy and vasoconstriction is more favorable for (+/-)-Bay W 5035 or (+/-)-Bay T 5006.
摘要
我们研究了新型钙激动剂（±）-Bay W 5035和（±）-Bay T 5006与（-）-S-Bay K 8644相比，对Langendorff大鼠心脏血流动力学和心外膜灌注的影响。2. 在等效应性肌力浓度下，（±）-Bay W 5035或（±）-Bay T 5006应用后冠状动脉阻力血管的血管收缩明显小于（-）-S-Bay K 8644应用后。3. FITC-葡聚糖3洗脱动力学表明，仅（-）-S-Bay K 8644可使心外膜血管容积显著降低。4. 此外，（-）-S-Bay K 8644比（±）-Bay W 5035或（±）-Bay T 5006更显著地增强了跨冠状动脉交换，反映了冠状动脉收缩活性的差异。5. 我们得出结论，与（-）-S-Bay K 8644相比，（±）-Bay W 5035或（±）-Bay T 5006在肌力作用和血管收缩之间的关系更为有利。
