• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The biological activities of trichosanthin after coupling to dextran.

作者信息

Ko W H, Yeung H W, Tam S C

机构信息

Department of Physiology, Chinese University of Hong Kong, Shatin, NT.

出版信息

Gen Pharmacol. 1993 May;24(3):757-62. doi: 10.1016/0306-3623(93)90242-p.

DOI:10.1016/0306-3623(93)90242-p
PMID:7690000
Abstract
  1. The major biological and pharmacological activities of trichosanthin (TCS) were retained after its covalent coupling to dextran T40. The potency and toxicity was generally reduced. 2. A dose of TCS as low as 0.02 mg/25 g induced 100% mid-term abortion whereas 20 times as much dextran-trichosanthin (DX-TCS) is required to produce the same effect. 3. A third of the mice died at a TCS dose of 0.1 mg/25 g but 4 times as much DX-TCS did not cause any death. 4. DX-TCS suppressed Con A or PHA induced lymphocyte transformation in a dose dependent manner. The potency was decreased as compared to TCS. 5. Both TCS and DX-TCS exhibited a cytostatic effect on cultured tumour cells (PU5 and hepatoma), the former being more potent.
摘要

相似文献

1
The biological activities of trichosanthin after coupling to dextran.
Gen Pharmacol. 1993 May;24(3):757-62. doi: 10.1016/0306-3623(93)90242-p.
2
Modulation of trichosanthin antigenicity by coupling to dextran.
Biochem Int. 1992 Dec;28(4):643-50.
3
Position 120-123, a potential active site of trichosanthin.第120 - 123位，是天花粉蛋白的一个潜在活性位点。
Life Sci. 1998;62(6):491-500. doi: 10.1016/s0024-3205(97)01145-4.
4
Minireview: trichosanthin--a protein with multiple pharmacological properties.小型综述：天花粉蛋白——一种具有多种药理特性的蛋白质。
Life Sci. 1994;55(4):253-62. doi: 10.1016/0024-3205(94)00727-6.
5
Importance of the Glu 160 and Glu 189 residues to the various biological activities of the ribosome inactivating protein trichosanthin.
Life Sci. 1996 May 24;58(26):2439-46. doi: 10.1016/0024-3205(96)00248-2.
6
Possible mechanisms of trichosanthin-induced apoptosis of tumor cells.天花粉蛋白诱导肿瘤细胞凋亡的可能机制。
Anat Rec (Hoboken). 2010 Jun;293(6):986-92. doi: 10.1002/ar.21142.
7
Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells.活性氧参与天花粉蛋白诱导的人绒毛膜癌细胞凋亡。
Biochem J. 2001 May 1;355(Pt 3):653-61. doi: 10.1042/bj3550653.
8
Lowering of trichosanthin immunogenicity by site-specific coupling to dextran.
Biochem Pharmacol. 1999 Apr 15;57(8):927-34. doi: 10.1016/s0006-2952(98)00364-5.
9
Structure-function relationship of trichosanthin.天花粉蛋白的结构-功能关系
Life Sci. 1997;60(7):465-72. doi: 10.1016/s0024-3205(96)00676-5.
10
Increasing the plasma half-life of trichosanthin by coupling to dextran.
Biochem Pharmacol. 1991 Oct 9;42(9):1721-8. doi: 10.1016/0006-2952(91)90508-3.

引用本文的文献

1
Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties.核糖体失活蛋白的工程改造用于改善药理学性质。
Toxins (Basel). 2020 Mar 9;12(3):167. doi: 10.3390/toxins12030167.