Fujii H, Nakagawa H, Sonoda Y, Kuzuyama Y
Third Department of Internal Medicine, Kyoto First Red Cross Hospital.
Rinsho Ketsueki. 1993 Jun;34(6):764-8.
This report deals with a case of RAEB in transformation (RAEB-T) who received peripheral blood stem cell transfusion (PBSCT) and has remained in complete remission for 15 months. A 51-year-old man was admitted to our hospital with abnormal hematological examinations in August 1991. Peripheral blood showed a WBC of 3,580/microliters with 19% myeloblasts. Bone marrow aspirate revealed slight hypocellularity with 21.2% myeloblasts. Many of these myeloblasts contained Auer rods. He was diagnosed as having RAEB-T. He was treated with low dose Ara-C, followed by the BHAC-VEP regimen and complete remission was obtained 2 months later. After high dose Ara-C regimen, one leukapheresis was performed using CS-3000 during bone marrow recovery. The collected number of CFU-GM, BFU-E and CFU-mix were 4.3, 4.3 and 0.68 x 10(5)/kg b.w., respectively and they were cryoreserved. In November 1991, 16 mg/kg b.w. of busulfan, 120 mg/kg b.w. of cyclophosphamide and rG-CSF were used as a conditioning regimen and PBSCT was performed. The infused number of CFU-GM, BFU-E and CFU -mix were 0.8, 0.9 and 0.14 x 10(5)/kg b.w., respectively. The number of days to reach 500 neutrophils/microliters and 5 x 10(4) platelets/microliters was 17 and 63 days, respectively. He has remained in complete remission for 15 months after PBSCT. PBSCT appears to be one effective therapeutic choice for the treatment of RAEB-T.
本报告涉及一例转化中的难治性贫血伴原始细胞过多（RAEB-T）患者，其接受了外周血干细胞输注（PBSCT）并已完全缓解15个月。一名51岁男性于1991年8月因血液学检查异常入院。外周血显示白细胞计数为3580/微升，原始粒细胞占19%。骨髓穿刺显示轻度细胞减少，原始粒细胞占21.2%。许多这些原始粒细胞含有奥氏小体。他被诊断为RAEB-T。他接受了小剂量阿糖胞苷治疗，随后采用BHAC-VEP方案，2个月后获得完全缓解。在高剂量阿糖胞苷方案后，在骨髓恢复期间使用CS-3000进行了一次白细胞单采。采集的集落形成单位-粒细胞巨噬细胞（CFU-GM）、爆式红系集落形成单位（BFU-E）和混合集落形成单位（CFU-mix）数量分别为4.3、4.3和0.68×10⁵/kg体重，并且进行了冷冻保存。1991年11月，使用16mg/kg体重的白消安、120mg/kg体重的环磷酰胺和重组人粒细胞集落刺激因子（rG-CSF）作为预处理方案并进行了PBSCT。输注的CFU-GM、BFU-E和CFU-mix数量分别为0.8、0.9和0.14×10⁵/kg体重。达到500个中性粒细胞/微升和5×10⁴个血小板/微升的天数分别为17天和63天。PBSCT后他已完全缓解15个月。PBSCT似乎是治疗RAEB-T的一种有效治疗选择。
