Nishikawa M, Ito S, Tokura T, Miki H
Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.
Nippon Ganka Gakkai Zasshi. 1993 Aug;97(8):913-9.
We could produce iris neovascularization experimentally in rhesus monkey eyes, by occlusion of the major retinal vessels of the retina and persistent ocular hypotony. We confirmed that panretinal photocoagulation inhibits development of iris neovascularization. We evaluated the effect of panretinal photocoagulation one month before occlusion of major retinal vessels with secondary iris neovascularization in 3 monkey eyes. Rubeosis iridis appeared on day 5 and disappeared on day 14 after retinal vessel occlusion. Histologically, the newly formed vessels near the iris surface showed fenestrations and protruded into the anterior chamber. The endothelial cells were flat and similar to matured vessels. These findings were in sharp contrast to our previous experiments with panretinal photocoagulation after rubeosis iridis became manifest. The findings also showed that retinal scarring by preceding panretinal photocoagulation did not completely inhibit the iris neovascularization.
我们可以通过阻塞恒河猴视网膜的主要血管并持续使眼压过低，在实验中诱导其虹膜新生血管形成。我们证实，全视网膜光凝可抑制虹膜新生血管的发展。我们评估了在3只猴眼中，于阻塞主要视网膜血管并继发虹膜新生血管形成前一个月进行全视网膜光凝的效果。视网膜血管阻塞后第5天出现虹膜红变，第14天消失。组织学检查显示，虹膜表面附近新形成的血管有窗孔，并突入前房。内皮细胞扁平，与成熟血管相似。这些发现与我们之前在虹膜红变明显后进行全视网膜光凝的实验结果形成鲜明对比。这些发现还表明，先前全视网膜光凝造成的视网膜瘢痕并不能完全抑制虹膜新生血管形成。
