Cetinkale O, Cizmeci O, Ayan F, Senyuva C, Pusane A
Department of Emergency and Burn Unit, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
Br J Plast Surg. 1993 Jul;46(5):410-5. doi: 10.1016/0007-1226(93)90047-f.
A 30% burn injury was found highly immunosuppressive in mice by means of two in vivo measurements of cell-mediated immunity, and this immunosuppression could be prevented by early excision and grafting. FK506, a new immunosuppressive agent, was given at different doses for 12 days after early excision and grafting following burn and all doses prolonged the acceptance time of allografts from 14 to 20 days. Allograft rejection was not seen when animals were on the drug. Higher doses prolonged the rejection more, even after the cessation of the drug, and they caused some degree of immunodepression. Immunosuppressive treatment with FK506 when used following burn injury affected cell-mediated immunity minimally to moderately when compared to burned control groups.
通过两种细胞介导免疫的体内测量方法发现，30%的烧伤对小鼠具有高度免疫抑制作用，而这种免疫抑制可通过早期切除和植皮来预防。新型免疫抑制剂FK506在烧伤后早期切除和植皮后，以不同剂量给药12天，所有剂量均将同种异体移植物的存活时间从14天延长至20天。动物使用该药物时未观察到同种异体移植物排斥反应。更高剂量的药物即使在停药后也能更显著地延长排斥反应时间，并且会导致一定程度的免疫抑制。与烧伤对照组相比，烧伤后使用FK506进行免疫抑制治疗对细胞介导免疫的影响为轻度至中度。
