Salter D M
Department of Pathology, University of Edinburgh Medical School.
Br J Rheumatol. 1993 Sep;32(9):780-6. doi: 10.1093/rheumatology/32.9.780.
Tenascin is a major extracellular glycoprotein known to have important functions in processes such as wound repair and embryogenesis including bone and cartilage formation. The expression of this molecule in articular cartilage and synovium from normal and abnormal (OA and inflammatory joint disease including RA) human knee joints was studied by an immunohistological technique using paraffin embedded tissue and a specific anti-human tenascin monoclonal antibody (BC4). The results show that in normal articular cartilage tenascin is expressed in small amounts in the surface zone and in synovium is present in significant levels in the walls of blood vessels only. In diseased joints expression is greatly increased both in articular cartilage and synovium. Increased production of tenascin is likely to be part of a reparative response in injured joints the understanding of which may suggest novel mechanisms to modify disease progression in degenerative and inflammatory joint disease.
腱生蛋白是一种主要的细胞外糖蛋白，已知其在诸如伤口修复和胚胎发生（包括骨和软骨形成）等过程中具有重要功能。利用石蜡包埋组织和特异性抗人腱生蛋白单克隆抗体（BC4），通过免疫组织学技术研究了该分子在正常和异常（骨关节炎和包括类风湿关节炎在内的炎性关节疾病）人膝关节的关节软骨和滑膜中的表达。结果表明，在正常关节软骨中，腱生蛋白仅在表面区域少量表达，而在滑膜中仅在血管壁中有显著水平的表达。在患病关节中，关节软骨和滑膜中的表达均大幅增加。腱生蛋白产生的增加可能是受损关节修复反应的一部分，对其的了解可能提示改变退行性和炎性关节疾病疾病进展的新机制。
