母体血清甲胎蛋白水平为5.0倍中位数倍数或更高时的价值以及产前超声检查对预测胎儿结局的作用。
Value of maternal serum alpha-fetoprotein levels of 5.0 MOM or greater and prenatal sonography in predicting fetal outcome.
作者信息
Larson J M, Pretorius D H, Budorick N E, Scioscia A L
机构信息
Department of Radiology, University of California, San Diego Medical Center.
出版信息
Radiology. 1993 Oct;189(1):77-81. doi: 10.1148/radiology.189.1.7690492.
PURPOSE
To determine fetal outcomes and the capability of sonography to help predict these outcomes in patients with maternal serum alpha-fetoprotein (MSAFP) levels of 5.0 multiples of the median or greater.
MATERIALS AND METHODS
Real-time sonography was performed in patients with singleton and multiple gestations. After sonography, the pregnancy was monitored.
RESULTS
Inaccurate historical dating caused elevated MSAFP levels in 14 patients. In the remaining 72 singleton gestations, 42 fetuses (58%) had anomalies, 13 (18%) died in utero or after birth, three (4%) had intrauterine growth retardation or were premature, and 14 (19%) were normal, with no complications. A poor outcome occurred in 58 (80%) of the singleton pregnancies, and sonography depicted an abnormality in 49 (84%) of these patients.
CONCLUSION
Most pregnant patients with MSAFP levels of 5.0 MOM or greater have an unfavorable outcome. Sonography depicts most of these abnormal pregnancies.
目的
确定母亲血清甲胎蛋白（MSAFP）水平为中位数的5.0倍或更高的患者的胎儿结局，以及超声检查预测这些结局的能力。
材料与方法
对单胎和多胎妊娠患者进行实时超声检查。超声检查后，对妊娠情况进行监测。
结果
14例患者因孕周推算不准确导致MSAFP水平升高。在其余72例单胎妊娠中，42例胎儿（58%）有异常，13例（18%）在宫内或出生后死亡，3例（4%）有宫内生长迟缓或早产，14例（19%）正常，无并发症。58例（80%）单胎妊娠结局不良，其中49例（84%）患者的超声检查显示有异常。
结论
大多数母亲血清甲胎蛋白水平为中位数5.0倍或更高的孕妇结局不佳。超声检查可显示出这些异常妊娠中的大多数情况。
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