免疫球蛋白VH3基因产物：HIV gp120的天然配体。
Immunoglobulin VH3 gene products: natural ligands for HIV gp120.
作者信息
Berberian L, Goodglick L, Kipps T J, Braun J
机构信息
Department of Pathology and Laboratory Medicine, University of California, Los Angeles 90024.
出版信息
Science. 1993 Sep 17;261(5128):1588-91. doi: 10.1126/science.7690497.
Infection with human immunodeficiency virus-type 1 (HIV-1) depletes T cells expressing CD4 and B cells expressing immunoglobulin (Ig) VH3 gene products. A subpopulation of normal B cells from non-HIV-infected individuals was shown to bind to HIV gp120 by means of membrane Ig; most of these B cells expressed VH3 family Ig. Serum VH3 IgM from uninfected individuals also avidly bound gp120. Finally, gp120 selectively induced Ig secretion by VH3 B cells, indicating that the binding of gp120 functionally activated these cells. These results indicate that naturally occurring VH3 Ig is a second ligand for gp120 and a candidate superantigen for VH3 B cells.
感染1型人类免疫缺陷病毒（HIV-1）会使表达CD4的T细胞和表达免疫球蛋白（Ig）VH3基因产物的B细胞减少。研究表明，来自未感染HIV个体的正常B细胞亚群可通过膜Ig与HIV gp120结合；这些B细胞中的大多数表达VH3家族Ig。未感染个体的血清VH3 IgM也能强烈结合gp120。最后，gp120可选择性诱导VH3 B细胞分泌Ig，这表明gp120的结合在功能上激活了这些细胞。这些结果表明，天然存在的VH3 Ig是gp120的第二种配体，也是VH3 B细胞的候选超抗原。
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