Oyama T, Sakakibara T, Ozaki K, Tsujimoto H, Sasaki S, Sakakura C, Shimotsuma M, Hagiwara A, Kojima O, Takahashi T
First Dept. of Surgery, Kyoto Prefectural University of Medicine.
Gan To Kagaku Ryoho. 1993 Aug;20(11):1710-2.
We have developed a new dosage form, PEP-CH, consisting of peplomycin adsorbed onto small activated carbon particles. Ten patients with inoperable advanced esophageal cancer were treated with endoscopic local injection of PEP-CH combined with radiation using 60Co. Two of 5 patients who completed the treatment have survived over one year (19 and 23 months) now.