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Nitric oxide production by murine macrophages is inhibited by prolonged elevation of cyclic AMP.

作者信息

Bulut V, Severn A, Liew F Y

机构信息

Department of Immunology, University of Glasgow, UK.

出版信息

Biochem Biophys Res Commun. 1993 Sep 15;195(2):1134-8. doi: 10.1006/bbrc.1993.2162.

DOI:10.1006/bbrc.1993.2162
PMID:7690553
Abstract

Murine macrophages produce large amounts of nitric oxide (NO) on stimulation by interferon (IFN)-gamma and lipopolysaccharide (LPS) or a high concentration of LPS alone. Agents which increase intracellular cAMP levels inhibit cytokine production by macrophages. The effect of increased intracellular cAMP levels on NO production was investigated, using a murine macrophage cell line, J774. NO production was reduced by prolonged elevation of cAMP, but not by a transient increase.

摘要

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