Widdas W F, Baker G F
Department of Biology (Physiology), Royal Holloway and Bedford New College, University of London, Egham, Surrey, Great Britain.
Cytobios. 1993;74(297):111-40.
The kinetics of the erythrocyte anion exchanger which have been studied at high pH values have confirmed the importance of hydroxyl ions in the overall physiological roles of the band 3 protein in human red cells. Although usually characterised as a one-for-one anion exchanger, conditions have been identified which give the appearance of net transport. The present findings have uncovered new functional features consistent with the properties of anion transport in other tissues. The molecular models proposed to interpret the results could have wider applications to other cellular mechanisms. Some of these are discussed to illustrate the physiological implications which can be deduced from the novel kinetics of this unique membrane transport protein.
在高pH值条件下对红细胞阴离子交换器动力学的研究证实了氢氧根离子在人红细胞带3蛋白整体生理作用中的重要性。尽管通常将其表征为一对一的阴离子交换器，但已发现了一些能产生净转运现象的条件。目前的研究结果揭示了与其他组织中阴离子转运特性一致的新功能特征。为解释这些结果而提出的分子模型可能在其他细胞机制中有更广泛的应用。本文讨论了其中一些模型，以说明从这种独特膜转运蛋白的新动力学中可以推断出的生理意义。
